Fredrik TRULSSON

Early-Stage Researcher

LUMC Leiden, Netherlands
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The LUMC is a university medical centre for research, education and patient care with a high quality profile and a strong scientific orientation and ranks as the 6th best medical research institute in Europe (Shanghai 2015). It has a unique research practice, ranging from pure fundamental medical research to applied clinical research. This enables LUMC to offer patient care and education that is in line with the latest international insights and standards – and helps it to improve medicine and healthcare. The LUMC participates in the League of European Research Universities (LERU), a strong international network of 21 renowned research universities (www.leru.org). LUMC is also a member of the Coimbra group, placing it amongst the most prestigious universities in Europe.

 

About

Fredrik obtained his biomedicine Bachelor’s and Master’s degrees at Umeå University in Sweden. During his bachelor studies, he investigated the replication of individual RNA segments in Hantavirus infected cells at the Swedish Defence Research Agency. His research work then focused on the involvement of caveolae (a small cave-like invagination of the plasma membrane) in membrane repair by microscopy and texture analysis techniques. In addition, he investigated the function of the short fiber knob (a capsid protein of the virus particle) of the human enteric adenoviruses 40 and 41.

After obtaining his Master’s degree, Fredrik worked as a project assistant at the Department of Radiation Sciences at Umeå University. This research group cultured orthotopically transplanted neoplastic organoids, which can recapitulate the full spectrum of tumour development, and used this model system to identify subpopulations of cancer-associated fibroblasts in pancreatic cancer.

Fredrik is joining the UbiCODE programme to pursue his PhD in Alfred Vertegaal’s laboratory where he will investigate SUMO and Ubiquitin systems biology by Mass Spectrometry. The team will employ pulldown strategies to enable purification of SUMO and Ubiquitin conjugates together with inhibitors to study their dynamics. The power of Mass Spectrometry can enable them to unravel the cellular function of SUMO and Ubiquitin.