Fredrik obtained his biomedicine Bachelor’s and Master’s degrees at Umeå University in Sweden. During his bachelor studies, he investigated the replication of individual RNA segments in Hantavirus infected cells at the Swedish Defence Research Agency. His research work then focused on the involvement of caveolae (a small cave-like invagination of the plasma membrane) in membrane repair by microscopy and texture analysis techniques. In addition, he investigated the function of the short fiber knob (a capsid protein of the virus particle) of the human enteric adenoviruses 40 and 41.
After obtaining his Master’s degree, Fredrik worked as a project assistant at the Department of Radiation Sciences at Umeå University. This research group cultured orthotopically transplanted neoplastic organoids, which can recapitulate the full spectrum of tumour development, and used this model system to identify subpopulations of cancer-associated fibroblasts in pancreatic cancer.
Fredrik is joining the UbiCODE programme to pursue his PhD in Alfred Vertegaal’s laboratory where he will investigate SUMO and Ubiquitin systems biology by Mass Spectrometry. The team will employ pulldown strategies to enable purification of SUMO and Ubiquitin conjugates together with inhibitors to study their dynamics. The power of Mass Spectrometry can enable them to unravel the cellular function of SUMO and Ubiquitin.