Supervisor Project : Peptide inhibitors of Ub ligases to treat diabetes and diabetic complications
Thomas EILAND is Director of Protein and Peptide Chemistry at Novo Nordisk and former professor
of organic chemistry and chemical biology at The Technical University of Denmark, and
the Nanyang Technological University, Singapore. He is currently also affiliated
professor at the Department of Immunology and Microbiology, University of
Copenhagen. Both scientists at Novo Nordisk are the authors of numerous journal
publications and patents in their respective fields of research
The essential proteins that regulate cell metabolism are controlled at the level of protein stability by ubiquitylation, and this regulation can therefore contribute to a wide range of diseases. The overall process of ubiquitylation thus provides attractive targets for drug development. In this project we specifically wish to explore the E3 Ub ligases, which direct substrate proteins to the Ub–proteasome system. These ligases are virtually unexplored as drug targets and fall into two main groups: the HECT domain proteins and RING domain proteins. We will design and synthesize peptide-based inhibitors of these proteins and evaluate their potential as new drugs for the treatment of diabetes and diabetic complications. Integrated microfluidic and bead-based technologies that integrate combinatorial library synthesis and screening represent key technologies to be developed to support the efforts.