Supervisor Project : Understanding the complexity of polyUb signaling in mitophagy and proteostasis.
The MRC Protein Phosphorylation and Ubiquitylation Unit (PPU) at the University of Dundee is a world class research institute, in which researchers make use of cutting-edge technology to study cellular and molecular mechanisms that underpin a number of diseases such as neurological disorders, cancer and hypertension. Scientists at the MRC PPU tackle major long-term questions, with a focus on the regulation of eukaryotic cell biology and human disease by protein phosphorylation and ubiquitylation. The MRC PPU operates as a focal point between leading life scientists, pharmaceutical companies and clinicians, to get a deeper understanding of diseases and how to treat them. The MRC PPU is part of the the School of Life Sciences (SLS) of the University of Dundee (UNIVDUN) and therefore benefits from having both a university and research institute environment. The SLS is repeatedly voted one of 'the best places for a life scientist to work' by The Scientist magazine.
The main goals of Yogesh Kulathu’s lab at the MRC PPU are to understand how ubiquitylation regulates protein degradation and proteostasis. He obtained his PhD at the Max Planck Institute for Immunobiology and University of Freiburg, and he did his postdoctoral training at the MRC Laboratory of Molecular Biology, Cambridge. Research in his lab is mainly funded by the MRC and an ERC Starting grant. Yogesh is an EMBO Young Investigator and Lister Prize Research Fellow.