Supervisor Project : Decoding the NEDD8 signal
We have recently uncovered a diverse role of protein NEDDylation in the response to genotoxic and proteotoxic stress, which is independent of the established role for NEDD8 in CRL regulation. The NEDD8 response to the above-mentioned stimuli strictly depends on the formation of either poly-NEDD8 and mixed hybrid NEDD8-Ub chains respectively. Key objectives of the project are to dissect the molecular factors that control the formation of such signals and the mechanisms of recognition and processing either through the de-conjugation or proteolytic machineries (proteasome/autophagy pathways). Our goal is to determine the role of poly-NEDD8 and NEDD8-Ub hybrid chains as potential novel molecular signals for the cellular response to stress.