All our publications are available in a single repository ! 


2021

Zuzanna Kozicka, Nicolas H. Thomä. Haven't got a glue: Protein surface variation for the design of molecular glue degradersCell Chemical Biology (2021).
 
DOI : 10.1016/j.chembiol.2021.04.009

2020

Barbara Mojsa, Michael H. Tatham, Lindsay Davidson, Magda Liczmanska, Jane E. Wright, Nicola Wiechens, Marek Gierlinski, Tom Owen-Hughes and Ronald T. Hay. SUMO maintains the chromatin environment of human induced pluripotent stem cells. Preprint.
 
DOI : 10.1101/2020.12.22.423944
Robbert Q KimMohit MisraAlexis GonzalezInes TomaškovićDonghyuk ShinHermann SchindelinDmitri V FilippovHuib OvaaIvan ĐikićGerbrand J van der Heden van Noort (2020). Development of ADPribosyl Ubiquitin Analogues to Study Enzymes Involved in Legionella Infection. Chem. Eur. J. 2021, 27, 2506 – 2512
 
DOI : 10.1002/chem.202004590
Orhi Barroso-Gomila, Fredrik Trulsson, Veronica Muratore, Iñigo Canosa, Ana Rosa Cortazar, Coralia Perez, Mikel Azkargorta, Ibon Iloro, Arkaitz Carracedo, Ana M Aransay, Felix Elortza, Ugo Mayor, Alfred C. O. Vertegaal, Rosa Barrio, James D. Sutherland (2020). Identification of proximal SUMO-dependent interacts using SUMO-ID. Preprint.
 
DOI : 10.1101/2020.12.28.424528
Ana Talamillo, Orhi Barroso-Gomila, Immacolata Giordano, Leiore Ajuria, Marco Grillo, Ugo Mayor, Rosa Barrio (2020). The role of SUMOylation during development. Biochemical Society Transactions 48, 463–478.
 
DOI : 10.1042/BST20190390

Laura Bozal-Basterra, María Gonzalez-Santamarta, Veronica Muratore, Aitor Bermejo-Arteagabeitia, Carolina Da Fonseca, Orhi Barroso-Gomila, Mikel Azkargorta, Ibon Iloro, Olatz Pampliega, Ricardo AndradeNatalia Martín-MartínTess C Branon, Alice Y Ting, Jose A Rodríguez, Arkaitz CarracedoFelix Elortza, James D Sutherland, Rosa Barrio (2020). LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome. eLife 9, e55957.

DOI : 10.7554/eLife.55957

Tom Cremer, Marlieke L.M. Jongsma, Fredrik Trulsson, Alfred C.O. Vertegaal, Jacques J.C. Neefjes, Ilana Berlin. The ER-embedded UBE2J1/RNF26 ubiquitylation complex exerts spatiotemporal control over the endolysosomal pathwayCell Reports 34, 108659, January 19, 2021

DOI : 10.1016/j.celrep.2020.108659

Zuzanna Kozicka, Georg Petzold, Nicolas H. Thomä. Taking the brakes off targeted protein degradation. Cell Chemical Biology 27, 16-18 (2020).

DOI :10.1016/j.chembiol.2019.12.010

Ganesh R. Pathare*, Alexiane Decout*, Selene Glück, Simone Cavadini, Kristina Makasheva, Ruud Hovius, Georg Kempf, Joscha Weiss, Zuzanna Kozicka, Baptiste Guey, Pauline Melenec, Beat Fierz, Nicolas H. Thomä‡ & Andrea Ablasser‡. Structural mechanism of cGAS inhibition by the nucleosomeNature (2020) (epub ahead of print).

DOI : 10.1038/s41586-020-2750-6

Cristina Mayor-Ruiz, Sophie Bauer, Matthias Brand, Zuzanna Kozicka, Marton Siklos, Hana Imrichova, Ines H. Kaltheuner, Elisa Hahn, Kristina Seiler, Anna Koren, Georg Petzold, Michaela Fellner, Christoph Bock, André C. Müller, Johannes Zuber, Matthias Geyer, Nicolas H. Thomä, Stefan Kubicek‡ & Georg E. Winter‡. Rational discovery of molecular glue degraders via scalable chemical profiling. Nat Chem Biol 16, 1199–1207 (2020).

DOI : 10.1038/s41589-020-0594-x

Rosa G. Lopez‐Reyes, Grégoire Quinet, Maria Gonzalez‐Santamarta, Clément Larrue, Jean‐Emmanuel Sarry, Manuel S. Rodriguez. Inhibition of the proteasome and proteaphagy enhances apoptosis in FLT3‐ITD‐driven acute myeloid leukemia. FEBS Open Bio (2020).

DOI: 10.1002/2211-5463.12950.

Mikołaj Słabicki*, Zuzanna Kozicka*, Georg Petzold#, Yen-Der Li, Manisha Manojkumar, Richard D. Bunker, Katherine A. Donovan, Quinlan L. Sievers, Jonas Koeppel, Dakota Suchyta, Adam S. Sperling, Emma C. Fink, Jessica A. Gasser, Li R. Wang, Steven M. Corsello, Rob S. Sellar, Max Jan, Dennis Gillingham, Claudia Scholl, Stefan Fröhling, Todd R. Golub, Eric S. Fischer, Nicolas H. Thomä‡ & Benjamin L. Ebert‡. The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K. Nature (2020).

DOI: 10.1038/s41586-020-2374-x

Ana Talamillo, Leiore Ajuria, Marco Grillo, Orhi Barroso-Gomila, Ugo Mayor, Rosa Barrio. SUMOylation in the control of cholesterol homeostasis. Open Biology (2020) 10:200054.
 
DOI: 10.1098/rsob.200054.

Grégoire Quinet, Maria Gonzalez-Santamarta, Clara Louche, Manuel S. Rodriguez. Mechanisms Regulating the UPS-ALS Crosstalk: The Role of Proteaphagy. Molecules 2020, 25, 2352.

DOI: 10.3390/molecules25102352.

Alicia K. Michael#, Ralph S. Grand#, Luke Isbel#, Simone Cavadini, Zuzanna Kozicka, Georg Kempf G, Richard D. Bunker, Andreas D. Schenk, Alexandra Graff-Meyer, Ganesh R. Pathare, Joscha Weiss, Syota Matsumoto, Lukas Burger, Dirk Schübeler, Nicolas H. Thomä. Mechanisms of OCT4-SOX2 motif readout on nucleosomes. Science 368, 1460-1465 (2020).

DOI: 10.1126/science.abb0074.

Maria Gonzalez-Santamarta, Grégoire Quinet, Diana Reyes-Garau, Brigitte Sola, Gaël Roué, Manuel S. Rodriguez (2020). Resistance to the Proteasome Inhibitors: Lessons from Multiple Myeloma and Mantle Cell Lymphoma. In: Barrio R., Sutherland J., Rodriguez M. (eds) Proteostasis and Disease. Advances in Experimental Medicine and Biology, vol 1233. Springer, Cham.

DOI: 10.1007/978-3-030-38266-7_6.

David A. Pérez Berrocal, Katharina F. Witting, Huib Ovaa and Monique P.C. Mulder (2020). Hybrid Chains: A Collaboration of Ubiquitin and Ubiquitin-Like Modifiers Introducing Cross-Functionality to the Ubiquitin Code. Front. Chem. 7:931.


2019

Nathalie Eisenhardt, Dragana Ilic, Easa Nagamalleswari, Andrea Pichler (2019). Chapter Eight - Biochemical characterization of SUMO-conjugating enzymes by in vitro sumoylation assays.  Methods in Enzymology, Academic Press, Volume 618, Pages 167-185. ISBN 9780128163597.

DOI: 10.1016/bs.mie.2018.12.025

James D. Sutherland, Orhi Barroso-Gomila and Rosa Barrio (2019). Biotin-based Approaches for the Study of Ubiquitin and Ubiquitin-like Protein Modifications. SUMOylation and Ubiquitination: Current and Emerging Concepts, Caister Academic Press, Pages 101-122. ISBN 978-1-912530-12-0.