Molecular glue degraders are a new class of drugs that work by facilitating an interaction between a disease-causing target protein and a ubiquitin ligase complex, destining the target protein for degradation. This video explains how a new molecular glue degrader compound called CR8 was identified, and why it is unlike any of the previously identified molecular glue degraders.

Molecular glue degraders are a new class of drugs that work by facilitating an interaction between a disease-causing target protein and a ubiquitin ligase complex, tagging the target protein for degradation. In this new video, members of the Thomä group, in collaboration with the Broad Institute, explain how they identified and characterized a new molecular glue degrader compound called CR8, showing that it is unlike any of the previously identified molecular glue degraders.