Post-translational modifications (PTM) by members of the Ubiquitin (Ub) family represent an efficient way to regulate almost every biological process. Defects in this homeostatic equilibrium, result in pathologies such as cancer, neurodegeneration, inflammation or multiple infections. For this reason, this research area has become very attractive for fundamental scientists as well as for the pharmaceutical industry aiming to identify potential targets for therapeutic intervention.
UbiCODE is a scientific consortium funded by the European Union, bringing together 11 research institutions across 5 European countries to decipher the ubiquitin code and train 13 PhD students in this field.
"Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less."
UbiCODE PhD fellows | Annual meeting | Bilbao | 24-25 February 2020
The key scientific mission of our students is to understand how protein modification with Ub/Ubls is generated (written), regulated (edited), recognised (read) and connected with effector functions (interpreted) to regulate cellular plasticity.